Cytogenetic risk stratification in chronic myelomonocytic leukemia
نویسندگان
چکیده
منابع مشابه
Cytogenetic risk stratification in chronic myelomonocytic leukemia.
BACKGROUND The prognostic value of cytogenetic findings in chronic myelomonocytic leukemia is unclear. Our purpose was to evaluate the independent prognostic impact of cytogenetic abnormalities in a large series of patients with chronic myelomonocytic leukemia included in the database of the Spanish Registry of Myelodysplastic Syndromes. DESIGN AND METHODS We studied 414 patients with chronic...
متن کاملTargeted deep sequencing improves outcome stratification in chronic myelomonocytic leukemia with low risk cytogenetic features
Clonal cytogenetic abnormalities are found in 20-30% of patients with chronic myelomonocytic leukemia (CMML), while gene mutations are present in >90% of cases. Patients with low risk cytogenetic features account for 80% of CMML cases and often fall into the low risk categories of CMML prognostic scoring systems, but the outcome differs considerably among them. We performed targeted deep sequen...
متن کاملChronic Myelomonocytic Leukemia: Current Classification, Diagnosis and Risk Stratification
CMML is a clonal malignant myeloid disorder sharing features of myelodysplastic syndromes and chronic myeloproliferative neoplasms. It is characterized by peripheral blood monocytosis, dysplastic features in at least 1 hematopoietic cell line and increased risk of progression to AML [1]. CMML has a male preponderance (1.5-3.0:1) [2]. The median age at diagnosis of CMML is about 70 years [3]. Th...
متن کاملCytogenetic and molecular abnormalities in chronic myelomonocytic leukemia.
Chronic myelomonocytic leukemia (CMML) is a clonal stem cell disorder associated with peripheral blood monocytosis and an inherent tendency to transform to acute myeloid leukemia. CMML has overlapping features of myelodysplastic syndromes and myeloproliferative neoplasms. Clonal cytogenetic changes are seen in ~30%, whereas gene mutations are seen in >90% of patients. Common cytogenetic abnorma...
متن کاملPrognosis of chronic myelomonocytic leukemia.
BACKGROUND Cytopenia caused by ineffective hematopoiesis and monocyte overproduction coexist in CMML, providing grounds for discussion to supporters of a dysplastic versus a proliferative identity for CMML. Follow-up information from a large series of patients may contribute to clarifying the position of this infrequent disease. METHODS We analyzed data from 77 patients followed in five insti...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2010
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2010.030957